Chapter 41: Anti-inflammatory Drugs

Overview Inflammation is a normal, protective response to tissue injury caused by physical trauma, noxious chemicals, or microbiologic agents. Inflammation is the body’s effort to inactivate or destroy invading organisms, remove irritants, and set the stage for tissue repair. When healing is complete, the inflammatory process usually subsides. However, inappropriate activation of our immune system […]

Chapter 42: Autacoids and Autacoid Antagonists

Overview Prostaglandins, histamine, and serotonin belong to a group of endogenous compounds called autacoids. These heterogeneous substances have widely differing structures and pharmacologic activities. They all have the common feature of being formed by the tissues on which they act and, therefore, function as local hormones. [Note: The word “autacoid” comes from the Greek: autos […]

Chapter 43: Toxicology

Overview Toxicology seeks to characterize the potentially adverse effects of foreign chemicals and their dose–response relationships to protect public health. Toxicology is defined as the study of the adverse effects of chemicals on living organisms. The term “toxicity” is defined as the inherent capacity of a chemical to cause injury (which is related to dose […]